The Hardest Problem AI Ever Solved, with Google DeepMind CEO

He solved “the most important unsolved problem in science”… If you need more optimistic science and tech stories, subscribe to support HUGE*! Demis Hassabis is a Nobel Prize winner and CEO of Google DeepMind. He is one of the most important people alive on what is quickly becoming the biggest technological advance of our lifetime. Because the biggest way AI is going to impact your life, you can’t see. It’s not a chatbot or an image generator. It’s the tools he and his team are building that are invisible to you – in new drug design, nuclear fusion, natural disasters detection, quantum computers. So who Demis is and what he chooses to build matters a lot. And he’s fascinating… He’s a childhood chess prodigy who at 17 turned down a reportedly million dollar job offer from a gaming company to go to college instead, and then get a PhD in neuroscience. He founded his company DeepMind with a mission to “solve intelligence” – starting with beating video games. He sold that company to Google specifically because they promised to let DeepMind focus on scientific research. But as this has turned into the most intense technological battle in recent history, Demis is now in charge of much much more. He’s now behind basically everything Google does in AI. He’s making decisions that affect your life and millions of other lives every single day. So what is he planning to do with all that power? My goal is to show you the future Demis Hassabis wants to build, so you can decide for yourself what you think of it. Welcome to HUGE* Conversations. This interview was recorded on March 5, 2026 in London. Chapters 00:00 What is the best use of AI? 02:04 Who is Demis Hassabis? 03:58 What is AlphaFold? 06:15 Why did Demis win the Nobel Prize? 12:30 How is AlphaFold accelerating science? 16:47 What is the cutting edge of drug discovery? 19:13 How close are we to AI DNA editing? 21:52 What did Demis want AI to do? 25:39 What does AI actually do like now? 29:16 How can AI be creative? 34:24 What is AlphaGo? 37:22 What is AlphaZero? 43:09 How should governments use AI? 45:40 What are the biggest worries about AI? 48:00 What are we not worrying enough about with AI? 50:13 What can humans do that AI can’t? 55:17 Why does Demis want AGI? 58:17 How does Demis want to be remembered? 1:00:14 What do AI simulations do? 1:01:56 How should I prepare? 1:04:59 :) You can find me on Instagram here: https://www.instagram.com/cleoabram On TikTok here: https://www.tiktok.com/@cleoabram Or on Twitter here: https://twitter.com/cleoabram Bio: Cleo Abram is an Emmy-nominated independent video journalist. On her show, HUGE* If True, Cleo explores complex technology topics with rigor and optimism, helping her audience understand the world around them and see positive futures they can help build. Before going independent, Cleo was a video producer for Vox. She wrote and directed the Coding and Diamonds episodes of Vox’s Netflix show, Explained. She produced videos for Vox’s popular YouTube channel, was the host and senior producer of Vox’s first ever daily show, Answered, and was co-host and producer of Vox’s YouTube Originals show, Glad You Asked. Additional reading and watching: - The Thinking Game (documentary) : https://www.youtube.com/watch?v=d95J8yzvjbQ - AlphaGo - The Movie (documentary): https://www.youtube.com/watch?v=WXuK6gekU1Y&t=3159s - Veritasium's "AlphaFold - The Most Useful Thing AI Has Ever Done": https://www.youtube.com/watch?v=P_fHJIYENdI&list=WL&index=5&t=74s - Google DeepMind: The Podcast, "The future of intelligence | Demis Hassabis": https://www.youtube.com/watch?v=PqVbypvxDto&t=120s - AlphaGenome Announcement: https://deepmind.google/blog/alphagenome-ai-for-better-understanding-the-genome/ - AlphaFold paper in Nature: https://www.nature.com/articles/s41586-021-03819-2 - Isomorphic Labs: https://www.isomorphiclabs.com/ - Demis' definition of AGI: https://x.com/demishassabis/status/1925464027213468029 - WeatherLab (interactive site): https://deepmind.google.com/science/weatherlab -Material Science AI (GNoME): https://deepmind.google/blog/millions-of-new-materials-discovered-with-deep-learning/ - Quantum Computing AI (AlphaQubit): https://blog.google/innovation-and-ai/models-and-research/google-deepmind/alphaqubit-quantum-error-correction/ Vox: https://www.vox.com/authors/cleo-abram IMDb: https://www.imdb.com/name/nm10108242/ Gear I use: Camera: Sony A7SIII Lens: Sony 16–35 mm F2.8 GM Audio: Sennheiser SK AVX and Zoom H4N Pro Music: Musicbed, Tom Fox Follow along for more episodes of HUGE* If True: https://www.youtube.com/cleoabram?sub_confirmation=1 — Hey, welcome to the joke down low! What did the robot say to its leader? “AI, captain!” Find a way to use “captain” in a comment to let me know you’re a real one who made it to the end of the description :)